Rockefeller University neurobiologist Cori Bargmann spent the past year assembling expert teams and vetting research ideas. Arguably more ambitious than the Human Genome Project or the Apollo program, the Brain Research Advancing Innovative Neurotechnologies Initiative endeavors to demystify our least understood organ—and the one that makes us most human. The 12-year, $4.5-billion undertaking aims to establish links between brain function and behavior, and to develop tools that will help us finally get to the bottom of conditions such as Alzheimer’s, autism, and depression.  Now, she says, the real work begins.