After several denied appeals, including several from the United States Supreme Court, Georgia executed its only female death row inmate Wednesday morning.

Kelly Renee Gissendaner died by lethal injection of pentobarbital Wednesday at 12:21 a.m. at the state prison in Jackson. She was convicted of murder in the February 1997 slaying of her husband. She conspired with her lover, who stabbed Douglas Gissendaner to death.

Gissendaner was the first woman executed in the state in 70 years.